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What is CBDp?

Cannabis plant with CBDp

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Cannabis is the gift that keeps on giving in the botanical world. The chemical nature and value of cannabis are becoming increasingly evident as research into the plant progresses. For instance, nearly 150 organic chemical compounds formed by cannabis emerged after scientists identified the body’s natural enzymatic reactions. THC was previously considered to be the most potent psychoactive cannabis compound.

However, two new cannabinoids, tetrahydrocannabiphorol (THCp) and cannabidiphorol (CBDp) arrived in town in December 2019. CBDp and THCp are phytocannabinoids, described as substances that imitate the action of naturally occurring chemicals in the human body.

And what calls everyone’s attention is how THCp could be 30 times stronger than THC in terms of activating biological receptors in the body, according to research conducted by an Italian team of researchers.

Key Takeaways

  • CBDp (cannabidiphorol) and its counterpart THCp were identified in December 2019 as new cannabinoids with a unique seven-link side chain, different from the typical five-link side chain found in previously discovered cannabinoids.
  • Despite the intrigue surrounding its discovery, CBDp is not currently a major focus of research. This is because CBD, known for its non-psychoactive properties and limited receptor binding, shares a similar structure and biological activity, leading scientists to prioritize other cannabinoids like THCp.
  • Although research is preliminary, CBDp might share similar therapeutic benefits with CBD, such as anti-inflammatory, antioxidant, and anti-seizure properties. These potential effects warrant further scientific investigation.

What is CBDp?

Up until now, all cannabinoids discovered have had a molecular structure that included a five-link side chain. Since both THCp and CBDp have seven-link side chains, they stand out. This side-chain decides how well chemicals bind to the endocannabinoid system's CB1 and CB2 receptors. The greater the physical and cerebral effects, the better the binding.

Given the exciting discovery of THCp and what it could be capable of, CBDP is not a top priority for research, at least not for now. This is because we already know that cannabidiol, as a non-psychoactive component of the cannabis plant, does not bind to the CB1 and CB2 cannabinoid receptors as well as THC does. Therefore, a longer side chain is unlikely to help CBDp react more efficiently to the body's receptors.

For this reason, scientists are leaving its analysis on hold. CBDp can also have potential therapeutic benefits as we learn more about how it interacts with THCp and other cannabinoids. Only by venturing further into science will we be enabled to see a broader perspective of how cannabis interacts with our endocannabinoid system, albeit one could still be intertwined or complicated.

Moreover, although CBDp and THCp were discovered at the same time, the researchers chose to focus on THCp in their first experiment because it has the ability to imitate THC's therapeutic and psychoactive properties. Since CBDp and CBD have almost identical structures and biological activity, future studies could reveal that CBDp has anti-inflammatory, antioxidant, and anti-seizure properties comparable to, if not superior to, CBD.

Benefits of CBDp

Because CBDp interacts with the human endocannabinoid system, it could help with a number of therapeutic conditions. However, because research is so early, I caution against extrapolating too much from the very little data we know.

Laboratory tests suggest CBDp could be equally beneficial to CBD, as it might have mostly the same anti-inflammatory effects, as well as being antioxidant and anti-seizure. Part of the reason CBDp is thought to be useful is its unique molecular structure, with a seven-link side chain, allowing it to potentially interact with the body in a different or more effective way than CBD – which could enhance these effects and benefits.

It’s useful in the treatment of:

  • Anxiety
  • Depression
  • Stress
  • Epilepsy
  • Pain
  • Inflammation
  • Mood-regulation
  • Arthritis
  • Fibromyalgia
  • Multiple sclerosis
  • Breast cancer

Effects of CBDp

Because CBDp is a synthetic version, we have not studied it as extensively as CBD. Based on our current knowledge, we speculate that CBDp could act just like CBD in the body. For example, it might reduce inflammation, alleviate oxidative stress and modulate seizure activity.

However, to understand CBDp more thoroughly, we first need to prove that it has these effects. There could also be new and unexpected benefits of CBDp that are yet to be seen.

Here’s what you can expect from trying CBDP:

  • Stimulation
  • Relaxation
  • Calmness
  • Mood-enhancing effects
  • Anti-stress
  • Anti-anxiety
  • Anti-depression

CBDp Is Safe?

However, given that CBDp is chemically similar to CBD, which appears to be safe with few, if any, significant side-effects, it would appear to have a promising safety profile. Until its safety profile is established by controlled studies, consumers should use caution regarding CBDp.

CBDP vs CBD: Understanding the Differences 

Because CBDp and CBD have nearly identical molecular backbone structures, but CBDp features a seven-link side chain as opposed to the CBD’s five-link, it is possible that this discrepancy could alter how CBDp binds to endocannabinoid system’s receptors.

CBD is well-regarded as a non-psychoactive cannabinoid that impacts the CB1 and CB2 receptors, thus it’s unknown whether CBDp’s side chain’s extended length could serve to strengthen the effects of CBD (while still enabling the non-intoxicating influence), or alternatively could cause CBDp to bind differently enough to alter or inhibit CBD’s effects on cannabinoid receptors entirely.

Strains with CBDP

An even more intriguing conclusion of the analysis is the need to grow non-THC or CBD-dominant cannabis strains. Cannabis genetics research has advanced by leaps and bounds in recent times, and varieties that contain higher levels of minor cannabinoids like CBDV, CBG, and THCV are becoming more widely available.

However, it is pretty evident that there are a couple more years before we have a small list of strains we can categorize as high in CBDp. Cannabis varieties high in other minor cannabinoids, such as THCp, may follow suit in the near future.

Furthermore, cultivating strains abundant in these minor cannabinoids allows extracting certain compounds faster, helping users enjoy the benefits of each compound's unique medical profile. Minor cannabinoids and currently unknown cannabinoids could indeed provide therapeutic benefits, with the promise of deeply transforming medicine or not.

But it's worth the effort to figure it out. Genetic studies and selective breeding have resulted in significantly higher concentrations of minor cannabinoids being available in past years. As we prepare and see what additional information on these newly found cannabinoids shows, potential product lines’ expectations become attractive. Until then, CBDp is in the list, waiting its turn to shine once someone with the knowledge finds interest in this compound full of promise.

What is CBDp: Frequently Asked Questions

Is CBDp Stronger Than CBD?

CBDp, like CBD, has a seven-link side chain attached to a ring structure, instead of a five-chain side chain. And since the greater number of links in the newly formed molecule could enhance its ability to bind with the body’s cannabinoid receptors, experts believe that CBDp might amplify the effects of CBD. It is still currently unknown if CBDp is actually stronger than CBD. That is something we may need to research, review and conclude, but initial hypotheses and claims suggest that CBDp might have heightened effects.

Is CBDp Psychoactive?

The structural similarity to CBD possibly suggests that CBDp is also non-psychoactive, and will not produce sensations of being ‘high’, which are identifiable from another well-known cannabinoid: THC, tetrahydrocannabinol. Rather than being psychoactive, therefore, it is in the therapeutic potential of CBDp where focus will continue to lie, alongside further investigation of this issue. As the years pass, perhaps we will come to better understand whether or not CBDp is psychoactive, although for now, it seems unlikely.

What Does CBDp Do?

It isn’t yet clear exactly what those effects are or, if it does have any result, what the health benefits might be because it’s very new and little researched. But since CBDp is probably very similar to the parent compound, CBD, we might assume that it has something of its ant-inflammatory, antioxidant and anti-seizure properties, suggesting a potential medicinal application for a wide range of conditions, including inflammatory pain, oxidative stress and epilepsy. But until there is more research, it’s hard to say what the full extent and mechanism of its action on the human body might be.

References For This Article:

  • https://www.nature.com/articles/s41598-019-56785-1
  • https://pubmed.ncbi.nlm.nih.gov/17245363/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467640/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223341/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/

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